![]() ![]() Overall, our study identifies a GSL signature that inhibits immune recognition and represents a potential therapeutic target in cancer, infection, and autoimmunity. We show that the immunomodulatory effect could be reversed through GSL synthesis inhibition using clinically approved drugs. Furthermore, a disturbed SPP元-B3GNT5 pathway in glioma correlated with decreased patient survival. waves of narrowly defined genres, leading to a perception of triteness. These GSLs sterically impeded antibody and receptor interactions with HLA-I and diminished CD8+ T cell activation. Artists and repertoire (colloquially abbreviated to A&R) is the division of a record label. : a supply of skills, devices, or expedients. We show that absence of the protease SPP元 augmented B3GNT5 enzyme activity, resulting in upregulation of surface neolacto-series GSLs. : a list or supply of dramas, operas, pieces, or parts that a company or person is prepared to perform. Using iterative genome-wide screens, we uncovered that the cell surface glycosphingolipid (GSL) repertoire determines effective HLA-I antigen presentation. The Peanut-Specific TCR Repertoire: A Statistical Approach to Define Homology Among CDR3 Sequences in Peanut-Allergic Individuals. Because options for restoring HLA-I antigen presentation are limited, we aimed to identify druggable HLA-I pathway targets. This process is often hijacked by tumors and pathogens for immune evasion. Show more HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. Overall, our study identifies a GSL signature that. These GSLs sterically impeded antibody and receptor interactions with HLA-I and diminished CD8+ T cell activation. Repertoire is three syllables rep-er-toire. repertoire noun a collection of works (plays, songs, operas, ballets) that an artist or company can perform and do perform for short intervals on a regular. We show that absence of the protease SPP元 augmented B3GNT5 enzyme activity, resulting in upregulation of surface neolacto-series GSLs. In theatre, the term in repertoire denotes the performance of two or more ballets or plays by the came company in the same venue, but on different evenings over a period of time. Using iterative genome-wide screens, we uncovered that the cell surface glycosphingolipid (GSL) repertoire determines effective HLA-I antigen presentation. The SPP元-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses Article / Letter to editor HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. ![]()
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